Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae
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چکیده
منابع مشابه
Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae
The mechanism of action of valproate (VPA), a widely prescribed short chain fatty acid with anticonvulsant and anticancer properties, remains poorly understood. Here, the yeast Saccharomyces cerevisiae was used as model to investigate the biological consequences of VPA exposure. We found that low pH strongly potentiates VPA-induced growth inhibition. Transcriptional profiling revealed that unde...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep36013